Neuro-Behcet's disease presenting with amnesia and frontal dysfunction

Received 28 September 2008; received in revised form 4 August 2009; accepted 6 August 2009.

Abstract

We report a 48-year-old patient with neuro-Behcet's disease who presented with the combination of severe memory impairment and frontal/executive dysfunction. The clinical feature mimicked that of diencephalic amnesic syndrome. The MRI and SPECT findings supported the notion that the thalamus and related subcortical–frontal connection was responsible for this patient's problem.

Keywords: Neuro-Behcet's disease, Amnesia, Frontal dysfunction, SPECT

a Department of Neuropsychiatry, Showa University School of Medicine, 5-11-11 Kita-Karasuyama, Setagaya-ku, Tokyo 157-8577, Japan

b Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan

Corresponding author at: Department of Neuropsychiatry, Showa University School of Medicine, 6-11-11 Kita-Karasuyama, Setagaya-ku, Tokyo 157-8577, Japan. Tel.: +81 3 3300 5232; fax: +81 3 3308 1710.

PII: S0303-8467(09)00205-4

doi:10.1016/j.clineuro.2009.08.002

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