Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease

Mito, Yasunori; Yoshida, Kazuto; Yabe, Ichiro; Makino, Kenichi; Hirotani, Makoto; Tashiro, Kunio; Kikuchi, Seiji; Sasaki, Hidenao

doi:10.1016/j.clineuro.2004.12.005

« Previous Next »Clinical Neurology and Neurosurgery
Volume 107, Issue 5 , Pages 396-403, August 2005

Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease

Yasunori Mito
- Department of Neurology, Asahikawa Red Cross Hospital,1-1, Akebono, Asahikawa, Hokkaido 070-8530, Japan
- Corresponding author. Tel.: +81 166 22 8111; fax: +81 166 22 5108.
Kazuto Yoshida
- Department of Neurology, Asahikawa Red Cross Hospital,1-1, Akebono, Asahikawa, Hokkaido 070-8530, Japan
Ichiro Yabe
- Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
Kenichi Makino
- Department of Neurosurgery, Asahikawa Red Cross Hospital, Asahikawa, Hokkaido, Japan
Makoto Hirotani
- Department of Neurology, Asahikawa Red Cross Hospital,1-1, Akebono, Asahikawa, Hokkaido 070-8530, Japan
Kunio Tashiro
- School of Psychological Science, Health Sciences University of Hokkaido, Sapporo, Hokkaido, Japan
Seiji Kikuchi
- Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
Hidenao Sasaki
- Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

Received 13 September 2004; received in revised form 22 November 2004; accepted 10 December 2004.

Abstract

Objectives:

Cerebral blood flow was compared among patients with dementia with Lewy bodies (DLB), Parkinson's disease with dementia (PDD), Parkinson's disease without dementia (PD), and Alzheimer's disease (AD) using three-dimensional stereotactic surface projection (3D-SSP) analysis.

Purpose:

We attempt to clarify the difference of reduction pattern on SPECT among patients having DLB, PDD, PD, AD.

Patients and Methods:

Six patients with DLB, 7 patients with PDD who were matched with the DLB patients for age, unified Parkinson's disease rating scale-III (UPDRS-III) score, and degree of cognitive function disorders, 21 patients with PD who were matched with the DLB patients for age, UPDRS-III score, 12 patients with AD who were matched with the DLB patients for age and degree of cognitive function disorders, and 12 control subjects. All patients were examined by N-isopropyl-p[¹²³I] iodoamphetamine single photon emission computed tomography (¹²³I-IMP SPECT), and obtained images were analyzed with 3D-SSP using an image-analysis software, iSSP ver. 3.5.

Results:

Although DLB and PDD showed similar cerebral perfusion reduction pattern at the lateral parietal association and lateral temporal association and precuneus on SPECT by the pixel-by-pixel comparison, greater perfusion reduction was observed in DLB than in PDD. Cerebral perfusion was decreased at the occipital lobe of the DLB patients compared with the AD patients.

Conclusions:

The regional pattern of blood flow reduction in the brain was found to be different among DLB, PD, and AD. Greater blood flow reduction was observed in DLB, although DLB and PDD showed similar reduction pattern. These regional differences were considered to suggest different and disease-specific combinations of underlying pathological and neurochemical processes.

Keywords: Dementia with Lewy bodies, Parkinson's disease, Parkinson's disease with dementia, Alzheimer's disease, SPECT, 3D-SSP