Clinical Neurology and Neurosurgery
Volume 109, Issue 8 , Pages 713-715, October 2007

Transient encephalopathy in a postoperative non-alcoholic female with Marchiafava-Bignami disease

  • Lesli E. Rusche-Skolarus

      Affiliations

    • Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States
    • Corresponding Author InformationCorresponding author at: Department of Neurology, Washington University School of Medicine, 660 South Euclid, Box 8111, St. Louis, MO 63110, United States. Tel.: +1 314 362 5262; fax: +1 314 362 3789.
    • ,
  • Brendan P. Lucey

      Affiliations

    • Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States
    • ,
  • Katie D. Vo

      Affiliations

    • Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States
    • ,
  • B. Joy Snider

      Affiliations

    • Department of Neurology, Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, United States

Received 17 December 2006; received in revised form 28 April 2007; accepted 11 May 2007.

Abstract 

Marchiafava-Bignami disease (MBD) is historically reported in middle-aged alcoholic men. We describe the presentation, course and radiological findings of a young non-alcoholic woman who developed encephalopathy and MRI findings consistent with MBD postoperatively. She returned to baseline after vitamin supplementation. We believe it is important to diagnose MBD because it is a potentially reversible encephalopathy.

Keywords: Encephalopathy, Marchiafava-Bignami disease, Malnutrition, Corpus callosum

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PII: S0303-8467(07)00138-2

doi:10.1016/j.clineuro.2007.05.005

Clinical Neurology and Neurosurgery
Volume 109, Issue 8 , Pages 713-715, October 2007

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