Clinical Neurology and Neurosurgery
Volume 109, Issue 10 , Pages 896-901 , December 2007

Leptomeningeal disease in chronic lymphocytic leukemia

  • C.P.E. Lange

      Affiliations

    • Departments of Neurology and Internal medicine, Medical Centre, The Hague, The Netherlands
    • Corresponding Author InformationCorresponding author at: Neuro-oncology Unit, Department Neurology, Medical Centre, POB 432, 2501 CK, The Hague, The Netherlands. Tel.: +31 6 14793500; fax: +31 182 505519.
  • ,
  • R.E. Brouwer

      Affiliations

    • Departments of Neurology and Internal medicine, Medical Centre, The Hague, The Netherlands
  • ,
  • R. Brooimans

      Affiliations

    • Department of Tumor Immunology, Erasmus Medical Centre, Rotterdam, The Netherlands
  • ,
  • Ch.J. Vecht

      Affiliations

    • Departments of Neurology and Internal medicine, Medical Centre, The Hague, The Netherlands

Received 11 April 2007 ,Revised 3 July 2007 ,Accepted 25 July 2007.

References 

  1. Oscier D, Fegan C, Hillmen P, et al. Diagnosis, management, and survival of patients with leptomeningeal cancer based on cerebrospinal fluid-flow status. Br J Haematol. 2004;125(3):294–317
  2. Jenkins A, Findlay G. In:  Peckham M,  Pinedo HM,  Veronesi U editor. Oxford textbook of oncology. 2nd ed.. Oxford medical publication; 1995;p. 2276–2286
  3. Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46:219–234
  4. Cash J, Fehir KM, Pollack MS. Meningeal involvement in early stage chronic lymphocytic leukemia. Cancer. 1987;59:798–800
  5. Cramer SC, Glaspy JA, Efird JT, Louis DN. Chronic lymphocytic leukemia and the central nervous system: A clinical and pathological study. Neurology. 1996;46:19–25
  6. Miller K, Budke H, Orazi A. Leukemic meningitis complicating early stage chronic lymphocytic leukemia. Arch Pathol Lab Med. 1997;121:524–527
  7. Morrison C, Shah S, Flinn IW. Leptomeningeal involvement in chronic lymphocytic leukemia. Cancer Pract. 1998;6:223–228
  8. Glantz MJ, Hall WA, Cole BF, et al. Diagnosis, management, and survival of patients with leptomeningeal cancer based on cerebrospinal fluid-flow status. Cancer. 1995;75(12):2919–2931
  9. Ito U, Tomita H, Yamazaki S, Takada Y, Inaba Y. CT findings of leptomeningeal and periventricular dissemination of tumors. Report of four cases. Clin Neurol Neurosurg. 1986;88(2):115–120
  10. Schinstine M, Filie AC, Wilson W, Stetler-Stevenson M, Abati A. Detection of malignant hematopoietic cells in cerebral spinal fluid previously diagnosed as atypical or suspicious. Cancer. 2006;108:157–162
  11. Bromberg JE, Breems DA, Kraan J, et al. CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies. Neurology. 2007;68(20):1674–1679
  12. Matutes E, Owusu-Ankomah K, Morilla R, et al. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia. 1994;8:1640–1645
  13. Moureau EJ, Mutates E, A’Hern AM, et al. Improvement of the chronic lymphocytic leukaemia scoring system with monoclonal antibody SN8 (CD79b). Am J Clin Pathol. 1997;108:378–382
  14. Glantz MJ, Jaeckle KA, Chamberlain MC, et al. A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin Cancer Res. 1999;5(11):3394–3402
  15. Bokstein F, Lossos A, Lossos IS, Siegal T. Central nervous system relapse of systemic non-Hodgkin's lymphoma: results of treatment based on high-dose methotrexate combination chemotherapy. Leuk Lymphoma. 2002;43(3):587–593
  16. Siegel T. Leptomeningeal metastases: rationale for systemic chemotherapy or what is the role of intra-CSF-chemotherapy?. J Neurooncol. 1998;38(2–3):151–157
  17. Korsager S, Laursen B, Mortensen TM. Dementia and central nervous system involvement in chronic lymphocytic leukemia. Scand J Haematol. 1982;29:283–286
  18. Grisold W, Jellinger K, Lutz D. Human neurolymphomatosis in a patient with chronic lymphocytic leukemia. Clin Neuropathol. 1990;9:224–230
  19. Rubin P, Harris NL. Case records of the Massachusetts general hospital: Case 4. A 73-year-old man with severe facial pain, visual loss, decreased ocular motility, and an orbital mass. N Engl J Med. 1993;328:266–275
  20. Akintola-Ogunremi O, Whitney C, Mathur SC, Finch CN. Chronic lymphocytic leukemia presenting with symptomatic central nervous system involvement. Ann Hematol. 2002;81:402–404
  21. Boogerd W, Vroom TM. Meningeal involvement as the initial symptom of B cell chronic lymphocytic leukemia. Eur Neurol. 1986;25:461–464
  22. Barcos M, Lane W, Gomez GA, et al. An autopsy study of 1206 acute and chronic leukemias (1958 to 1982). Cancer. 1987;60:827–837
  23. Finn WG, Peterson LC, James C, Goolsby CL. Enhanced detection of malignant lymphoma in cerebrospinal fluid by multiprameter flow cymetry. Am J Clin Pathol. 1998;110(3):341–346
  24. Roma AA, Garcia A, Avagnina A, Elsner B. Lymphoid and myeloid neoplasm involving cerebrospinal fluid: comparison of morphologic examination and immunophenotyping by flow cytometry. Diagn Cytopathol. 2002;27(5):271–275
  25. French CA, Dorfman DM, Shaheen G, Cibas ES. Diagnosing lymphoproliferative disorders involving the cerebrospinal fluid: increased sensitivity using flow cytometric analysis. Diagn Cytopathol. 2000;23(6):369–374
  26. Amiel JL, Droz JP. Lymphocytose rachidienne au cours de la leucémie lymphocytaire chronique. vol. 5. La Nouv Presse Méd; 1976;pp. 94–95
  27. Sullivan AK, Vera JC, Jerry LM, Rowden G, Bain B. Small Lymphocyte T-cell leukemia in the adult. Cancer. 1978;42:2920–2927
  28. Getaz EP, Miller GJ. Spinal cord involvement in chronic lymphocytic leukemia. Cancer. 1979;43:1858–1861
  29. Liepman MK, Votaw L. Meningeal complication chronic lymphocytic leukemia. Cancer. 1981;47:2482–2484
  30. Oshimi K, Akahoshi M, Hagiwara N, Tanaka M, Mizoguchi H. A case of T-cell chronic lymphocytic leukemia with an unusual phenotypic and central nervous system involvement. Cancer. 1985;55:1937–1942
  31. Steinberg JP, Pecora M, Lokey JL. Leukemic meningitis in B-cell chronic lymphocytic leukemia. Cancer Treat Rep. 1985;69:687–688
  32. Singh AK, Thompson RPH. Leukaemic meningitis in chronic lymphocytic leukemia. Acta Haematol. 1986;75:113–115
  33. Currie JN, Simmons L, Lessel IM, Weiss JS, Albert DM, Benson EM. Optic neuropathy in chronic lymphocytic leukemia. Arch Ophthalmol. 1988;106:654–660
  34. Stagg MP, Gumbart CH. chronic lymphocytic leukemic meningitis as a cause of the syndrome of inappropriate secretion of antidiuretic hormone. Cancer. 1987;60:191–192
  35. Garofalo M, Murali RAJ, Halperin I, Magardician K, Moussouris HF, Masdeu JC. Chronic lymphocytic leukemia with hypothalamic invasion. Cancer. 1989;64:1714–1716
  36. Lopez Guillermo A, Cervantes F, Blade J, et al. Central nervous system involvement demonstrated by immunological study in prolymphocytic variant of chronic lymphocytic leukemia. Acta Haematol. 1989;81:109–111
  37. Ruiz P, Moezzi M, Chamizo W, Ganjei P, Whitcomb CC, Rey LC. Central nervous system expression of a monoclonal paraprotein in a chronic lymphocytic leukemia patient. Acta Haematol. 1992;88:37–40
  38. Fain JS, Naeim F, Becker DP, et al. Chronic lymphocytic leukemia presenting as a pituitary mass lesion. Can J Neurol Sci. 1992;19:239–242
  39. Thiruvengadam R, Bernstein ZP. Central nervous system involvement in prolymphocytic transformation of chronic lymphocytic leukemia. Acta Haematol. 1992;87:163–164
  40. Perez Fernandez I, Salgado Ordonez F. Infiltration of the central nervous system as a presentation form of early stage chronic lymphocytic leukemia. Am J Hematol. 1998;58:339–342
  41. Poplawska-Szczyglowska L, Walewski J, Pienkowska-Grela B, Rymkiewicz G, Mioduszewska . Chronic lymphocytic leukaemia presenting with central nervous system involvement. Med Oncol. 1999;16:65–68
  42. Elliot MA, Letendre L, Li C, Hoyer JD, Hammack JE. Chronic lymphocytic leukaemia with symptomatic diffuse central nervous system infiltration responding to therapy with systemic fludarabine. Br J Haematol. 1999;104:689–694
  43. Marmont AM. Leukemic meningitis in B-cell chronic lymphocytic leukemia: resolution following intrathecal methotrexate. Blood. 2000;96:776–777
  44. Rye AD, Stitson RN, Dyer MJ. Pituitary infiltration in B-cell chronic lymphocytic leukaemia. Br J Haematol. 2001;115:718
  45. Brick WG, Majmundar M, Hendricks LK, Kallab AM, Burgess RE, Jillella AP. Leukemic leptomeningeal involvement in stage 0 and stage 1 chronic lymphocytic leukemia. Leuk Lymphoma. 2002;43:199–201
  46. Kaiser U. Cerebral involvement as the initial manifestation of chronic lymphocytic leukaemia. Acta Haematol. 2003;109:193–195
  47. Remkova A, Bezayova T, Vyskocil M. B cell chronic lymphocytic leukemia with meningeal infiltration by T lymphocytes. Eur J Int Med. 2003;14:49–52
  48. Kuwabara H, Kanamori H, Takasaki H, et al. Involvement of central nervous system in prolymphocytoid transformation of chronic lymphocytic leukemia. Leuk Lymphoma. 2003;44:1235–1237

PII: S0303-8467(07)00202-8

doi: 10.1016/j.clineuro.2007.07.021

Clinical Neurology and Neurosurgery
Volume 109, Issue 10 , Pages 896-901 , December 2007