Clinical Neurology and Neurosurgery
Volume 109, Issue 10 , Pages 910-913, December 2007

Successful treatment of relapsing neuro-Sweet's disease with corticosteroid and dapsone combination therapy

  • Jiro Fukae

      Affiliations

    • Department of Neurology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka 410-2295, Japan
    • ,
  • Kazuyuki Noda

      Affiliations

    • Department of Neurology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka 410-2295, Japan
    • ,
  • Kenji Fujishima

      Affiliations

    • Department of Neurology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka 410-2295, Japan
    • ,
  • Ryo Wada

      Affiliations

    • Department of Pathology, Juntendo University Shizuoka Hospital, Shizuoka, Japan
    • ,
  • Takashi Yoshiike

      Affiliations

    • Department of Dermatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan
    • ,
  • Nobutaka Hattori

      Affiliations

    • Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    • ,
  • Yasuyuki Okuma

      Affiliations

    • Department of Neurology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka 410-2295, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 55 948 3111; fax: +81 55 948 5088.

Received 18 March 2007; received in revised form 29 July 2007; accepted 30 July 2007.

Abstract 

Sweet's disease with central nervous system involvement, tentatively named neuro-Sweet's disease, has rarely been reported. Although systemic corticosteroid therapy is highly effective for neurologic symptoms in neuro-Sweet's disease, relapse is common. Here, we describe the case of a 38-year-old Japanese man who presented with relapsing neuro-Sweet's disease that was successfully treated with a combination of corticosteroid and dapsone. Dapsone should be considered as a therapeutic option for neuro-Sweet's disease patients showing relapse.

Keywords: Neuro-Sweet's disease, Relapse, Corticosteroid, Dapsone, Cytokines

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PII: S0303-8467(07)00206-5

doi:10.1016/j.clineuro.2007.07.025

Clinical Neurology and Neurosurgery
Volume 109, Issue 10 , Pages 910-913, December 2007

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