Clinical Neurology and Neurosurgery
Volume 111, Issue 1 , Pages 87-93, January 2009

Systemic cancer metastasis in a meningioma: Report of two cases and review of the literature

  • Michele Lanotte

      Affiliations

    • Institute of Neurosurgery, Department of Neuroscience, University of Torino, Via Cherasco 15, I-10126 Torino, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 011 633 4243; fax: +39 011 633 4243.
    • ,
  • Franco Benech

      Affiliations

    • Institute of Neurosurgery, Department of Neuroscience, University of Torino, Via Cherasco 15, I-10126 Torino, Italy
    • ,
  • Pier Paolo Panciani

      Affiliations

    • Institute of Neurosurgery, Department of Neuroscience, University of Torino, Via Cherasco 15, I-10126 Torino, Italy
    • ,
  • Paola Cassoni

      Affiliations

    • Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    • ,
  • Alessandro Ducati

      Affiliations

    • Institute of Neurosurgery, Department of Neuroscience, University of Torino, Via Cherasco 15, I-10126 Torino, Italy

Received 9 April 2008; received in revised form 27 June 2008; accepted 1 July 2008.

Abstract 

“Tumour-to-tumour” phenomenon is a rare event; meningioma has been reported as the most common primary intracranial tumour to harbour metastases, the majority of which arise from breast and lung carcinomas. Several hypotheses have been previously proposed to explain this occurrence, but the exact mechanisms responsible for the development of metastases in meningiomas are not known. Magnetic resonance imaging (MRI) and spectroscopy could be useful to hypothesize this uncommon event, but its preoperative diagnosis remains highly difficult.

Two patients are reported, with breast and renal carcinoma metastases in an intracranial meningioma. Pathogenetic mechanisms and neuroimaging features are discussed. A brief review of the literature is presented.

Keywords: Tumour-to-tumour metastasis, Meningioma, Breast carcinoma, Clear cell renal carcinoma

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PII: S0303-8467(08)00264-3

doi:10.1016/j.clineuro.2008.07.011

Clinical Neurology and Neurosurgery
Volume 111, Issue 1 , Pages 87-93, January 2009

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