Clinical Neurology and Neurosurgery
Volume 111, Issue 10 , Pages 847-851 , December 2009

Plasma level of sICAM-1 is associated with the extent of white matter lesion among asymptomatic elderly subjects

  • Jing Hao Han

      Affiliations

    • Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong
    • Department of Neurology, 12 Wulumuqi Zhong Rd, Huashan Hospital, Fudan University, Shanghai, 200040, China
    • ,
  • Ka Sing Wong

      Affiliations

    • Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong
    • ,
  • Yan Yan Wang

      Affiliations

    • Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai, China
    • ,
  • Jian Hui Fu

      Affiliations

    • Department of Neurology, 12 Wulumuqi Zhong Rd, Huashan Hospital, Fudan University, Shanghai, 200040, China
    • ,
  • Ding Ding

      Affiliations

    • Department of Neurology, 12 Wulumuqi Zhong Rd, Huashan Hospital, Fudan University, Shanghai, 200040, China
    • ,
  • Zhen Hong

      Affiliations

    • Department of Neurology, 12 Wulumuqi Zhong Rd, Huashan Hospital, Fudan University, Shanghai, 200040, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 021 5288 8158; fax: +86 021 6248 1930.

Received 5 February 2009 ,Revised 14 August 2009 ,Accepted 17 August 2009.

References 

  1. Garde E, Mortensen EL, Krabbe K, Rostrup E, Larsson HB. Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Lancet. 2000;356:628–634
  2. Wen HM, Mok VC, Fan YH, Lam WW, Tang WK, Wong A, et al. Effect of white matter changes on cognitive impairment in patients with lacunar infarcts. Stroke. 2004;35:1826–1830
  3. Vermeer SE, Hollander M, van Dijk EJ, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke. 2003;34:1126–1129
  4. Springer TA. Adhesion receptors of the immune system. Nature. 1990;346:425–434
  5. Johnson-Tidey RR, McGregor JL, Taylor PR, Poston RN. Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1. Am J Pathol. 1994;144:952–961
  6. DeGraba TJ, Siren AL, Penix L, McCarron RM, Hargraves R, Sood S, et al. Increased endothelial expression of intercellular adhesion molecule-1 in symptomatic versus asymptomatic human carotid atherosclerotic plaque. Stroke. 1998;29:1405–1410
  7. Pradhan AD, Rifai N, Ridker PM. Soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and the development of symptomatic peripheral arterial disease in men. Circulation. 2002;106:820–825
  8. Fassbender K, Bertsch T, Mielke O, Muhlhauser F, Hennerici M. Adhesion molecules in cerebrovascular diseases. Evidence for an inflammatory endothelial activation in cerebral large- and small-vessel disease. Stroke. 1999;30:1647–1650
  9. Hassan A, Hunt BJ, O'Sullivan M, Parmar K, Bamford JM, Briley D, et al. Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain. 2003;126:424–432
  10. Fu JH, Lu CZ, Hong Z, Dong Q, Luo Y, Wong KS. Extent of white matter lesions is related to acute subcortical infarcts and predicts further stroke risk in patients with first ever ischaemic stroke. J Neurol Neurosurg Psychiatry. 2005;76:793–796
  11. Fu JH, Lu CZ, Hong Z, Dong Q, Ding D, Wong KS. Relationship between cerebral vasomotor reactivity and white matter lesions in elderly subjects without large artery occlusive disease. J Neuroimaging. 2006;16:120–125
  12. Gao S, Lam WW, Chan YL, Liu JY, Wong KS. Optimal values of flow velocity on transcranial Doppler in grading middle cerebral artery stenosis in comparison with magnetic resonance angiography. J Neuroimaging. 2002;12:213–218
  13. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology. 1993;43:1683–1689
  14. de Leeuw FE, de Groot JC, Oudkerk M, Witteman JC, Hofman A, van Gijn J, et al. Hypertension and cerebral white matter lesions in a prospective cohort study. Brain. 2002;125:765–772
  15. Longstreth WT, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke. 1996;27:1274–1282
  16. Kawamura T, Umemura T, Kanai A, Uno T, Matsumae H, Sano T, et al. The incidence and characteristics of silent cerebral infarction in elderly diabetic patients: association with serum-soluble adhesion molecules. Diabetologia. 1998;41:911–917
  17. Tomimoto H, Akiguchi I, Suenaga T, Nishimura M, Wakita H, Nakamura S, et al. Alterations of the blood–brain barrier and glial cells in white-matter lesions in cerebrovascular and Alzheimer's disease patients. Stroke. 1996;27:2069–2074
  18. Elbaz A, Poirier O, Moulin T, Chedru F, Cambien F, Amarenco P. Association between the Glu298Asp polymorphism in the endothelial constitutive nitric oxide synthase gene and brain infarction. The GENIC Investigators. Stroke. 2000;31:1634–1639
  19. Rudic RD, Sessa WC. Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links. Am J Hum Genet. 1999;64:673–677
  20. Endres M, Laufs U, Merz H, Kaps M. Focal expression of intercellular adhesion molecule-1 in the human carotid bifurcation. Stroke. 1997;28:77–82
  21. Felberg RA, Christou I, Demchuk AM, Malkoff M, Alexandrov AV. Screening for intracranial stenosis with transcranial Doppler: the accuracy of mean flow velocity thresholds. J Neuroimaging. 2002;12:9–14
  22. Fazekas F, Kleinert R, Offenbacher H, Payer F, Schmidt R, Kleinert G, et al. The morphologic correlate of incidental punctate white matter hyperintensities on MR images. AJNR Am J Neuroradiol. 1991;12:915–921
  23. Blanco-Colio LM, Martin-Ventura JL, de Teresa E, Farsang C, Gaw A, Gensini G, et al. Elevated ICAM-1 and MCP-1 plasma levels in subjects at high cardiovascular risk are diminished by atorvastatin treatment. Atorvastatin on Inflammatory Markers study: a substudy of Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration. Am Heart J. 2007;153:881–888
  24. Nakamura K, Masuda H, Kariyazono H, Arima J, Iguro Y, Yamada K, et al. Effects of atorvastatin and aspirin combined therapy on inflammatory responses in patients undergoing coronary artery bypass grafting. Cytokine. 2006;36:201–210
  25. Doo YC, Han SJ, Park WJ, Kim SM, Choi SH, Cho GY, et al. Associations between C-reactive protein and circulating cell adhesion molecules in patients with unstable angina undergoing coronary intervention and their clinical implication. Clin Cardiol. 2005;28:47–51
  26. Constans J, Conri C. Circulating markers of endothelial function in cardiovascular disease. Clin Chim Acta. 2006;368:33–47
  27. Markus HS, Hunt B, Palmer K, Enzinger C, Schmidt H, Schmidt R. Markers of endothelial and hemostatic activation and progression of cerebral white matter hyperintensities: longitudinal results of the Austrian Stroke Prevention Study. Stroke. 2005;36:1410–1414

PII: S0303-8467(09)00232-7

doi: 10.1016/j.clineuro.2009.08.018

Clinical Neurology and Neurosurgery
Volume 111, Issue 10 , Pages 847-851 , December 2009

Article Tools

* Image Usage & Resolution