Clinical Neurology and Neurosurgery
Volume 112, Issue 1 , Pages 29-31 , January 2010

Modafinil for multiple sclerosis fatigue: Does it work?

  • Edward T. Littleton

      Affiliations

    • Department of Clinical Neurology, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44 1455 611688.
    • ,
  • Jeremy C. Hobart

      Affiliations

    • Department of Clinical Neuroscience, Peninsula Medical School, Derriford Hospital, Plymouth PL6 8DH, United Kingdom
    • ,
  • Jacqueline Palace

      Affiliations

    • Department of Clinical Neurology, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, United Kingdom

Received 15 January 2009 ,Revised 19 August 2009 ,Accepted 22 September 2009.

References 

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  2. Broughton RJ, Fleming JA, George CF, Hill JD, Kryger MH, Moldofsky H, et al. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology. 1997;49(2):444–451
  3. Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy Multicenter Study Group. Neurology 2000;54(5):1166–75.
  4. Rammohan KW, Rosenberg JH, Lynn DJ, Blumenfeld AM, Pollak CP, Nagaraja HN. Efficacy and safety of modafinil (Provigil) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study. J Neurol Neurosurg Psychiatry. 2002;72:179–183
  5. Stankoff B, Waubant E, Confavreux C, Edan G, Debouverie M, Rumbach L, et al. Modafinil for fatigue in MS. A randomized placebo-controlled double-blind study. Neurology. 2005;64:1139–1143
  6. Schwid SR, Covington M, Segal BM, Goodman AD. Fatigue in multiple sclerosis: current understanding and future directions. J Rehabil Res Dev. 2002;39(2):211–224
  7. Krupp LB. Fatigue in multiple sclerosis: definition, pathophysiology and treatment. CNS Drugs. 2003;17(4):225–234
  8. Flachenecker P, Kumpfel T, Kallmann B, Gottschalk M, Grauer O, Rieckmann P, et al. Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters. Mult Scler. 2002;8(6):523–526
  9. Rothwell PM. External validity of randomised controlled trials: to whom do the results of this trial apply?. Lancet. 2005;365:82–93
  10. Taphoorn MJ, van Someren E, Snoek FJ, Strijers RL, Swaab DF, Visscher F, et al. Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis. J Neurol. 1993;240(7):446–448
  11. Attarian HP, Brown KM, Duntley SP, Carter JD, Cross AH. The relationship of sleep disturbances and fatigue in multiple sclerosis. Arch Neurol. 2004;61(4):525–528
  12. Freal JE, Kraft GH, Coryell JK. Symptomatic fatigue in multiple sclerosis. Arch Phys Med Rehabil. 1984;54:135–138

PII: S0303-8467(09)00258-3

doi: 10.1016/j.clineuro.2009.09.004

Clinical Neurology and Neurosurgery
Volume 112, Issue 1 , Pages 29-31 , January 2010

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