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Volume 112, Issue 3, Pages 177-182 (April 2010)


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Management of meningiomas

George A. AlexiouaCorresponding Author Informationemail addressemail address, Pinelopi Gogoub, Sofia Markoulac, Athanasios P. Kyritsiscd

Received 18 July 2009; received in revised form 14 October 2009; accepted 11 December 2009.

Abstract 

The primary treatment of meningiomas is surgery which can be curative if the tumor is completely removed. For parasagittal, lateral sphenoid wing and olfactory groove meningiomas, gross-total resection should be the goal. Tuberculum and diaphragma sella meningiomas can be resected through the subfrontal or the pterional approaches. In meningiomas of the sphenoid wing with osseous involvement or involvement of the cavernous sinus subtotal resection can be achieved via several surgical approaches. Similarly, subtotal resection rather than gross-total resection of meningiomas of the petroclival, parasellar, and posterior fossa regions can preserve neurological function. Prior to surgery, embolization may reduce intraoperative bleeding and prevent postoperative complications. Stereotactic radiosurgery can be used as an alternative treatment to surgery either as a first-line treatment or at recurrence. Various conventional radiotherapy techniques can be employed for residual tumor post surgery or at recurrence. Chemotherapy has modest activity and is reserved for selected cases.

a Department of Neurosurgery, University Hospital of Ioannina, Greece

b Department of Radiation Oncology, Aretaieio Hospital, University of Athens Medical School, Athens, Greece

c Department of Neurology, University Hospital of Ioannina, Greece

d Neurosurgical Research Institute, University of Ioannina School of Medicine, Ioannina, Greece

Corresponding Author InformationCorresponding author at: P.O. Box 103, Neohoropoulo, Ioannina 45500, Greece. Tel.: +30 26510 48795/69485 25134; fax: +30 26510 99700.

PII: S0303-8467(09)00344-8

doi:10.1016/j.clineuro.2009.12.011


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