Clinical Neurology and Neurosurgery
Volume 112, Issue 4 , Pages 286-290 , May 2010

Brain MRI findings in long-standing and disabling multiple sclerosis in 84 patients

  • Dimitri Renard

      Affiliations

    • Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029 Nîmes Cedex 4, France
    • ,
  • Giovanni Castelnovo

      Affiliations

    • Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029 Nîmes Cedex 4, France
    • ,
  • Philippe-Jean Bousquet

      Affiliations

    • BESPIM – Département de Biostatistique, Epidémiologie Clinique, Sante Publique et Information Médicale, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029 Nîmes, France
    • ,
  • Nicolas de Champfleur

      Affiliations

    • Department of Neuroradiology, CHU Montpellier, Hôpital Gui de Chauliac, 80 Avenue Augustin Fliche, 34295 Montpellier, France
    • ,
  • Jérôme de Seze

      Affiliations

    • Department of Neurology, CHU Strasbourg, Hôpital Civil, 1 Place de l’Hôpital, 67091 Strasbourg, France
    • ,
  • Patrick Vermersch

      Affiliations

    • Department of Neurology, CHU Lille, Hôpital Roger Salengro, Rue Emile Laine, 59037 Lille, France
    • ,
  • Pierre Labauge

      Affiliations

    • Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029 Nîmes Cedex 4, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 4 66 68 32 61; fax: +33 4 66 68 40 16.

Received 4 June 2009 ,Revised 11 December 2009 ,Accepted 15 December 2009.

References 

  1. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol. 2005;58:840–846
  2. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50:121–127
  3. Brex PA, Ciccarelli O, O’Riordan JI, Sailer M, Thompson AJ, Miller DH. A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N Engl J Med. 2002;346:158–164
  4. Tintoré M, Rovira A, Río J, Nos C, Grivé E, Sastre-Garriga J, et al. New diagnostic criteria for multiple sclerosis: application in first demyelinating episode. Neurology. 2003;60:6–7
  5. Barkhof F, Filippi M, Miller DH, Scheltens P, Campi A, Polman CH, et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain. 1997;120:2059–2069
  6. Dalton CM, Brex PA, Miszkiel KA, Hickman SJ, MacManus DG, Plant GT, et al. Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis. Ann Neurol. 2002;52:47–53
  7. Optic Neuritis Study Group . Long-term brain magnetic resonance imaging changes after optic neuritis in patients without clinically definite multiple sclerosis. Arch Neurol. 2004;61:1538–1541
  8. Fisniku LK, Brex PA, Altmann DR, Miszkiel KA, Benton CE, Lanyon R, et al. Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain. 2008;131:808–817
  9. Nijeholt GJ, van Walderveen MA, Castelijns JA, van Waesberghe JH, Polman C, Scheltens P, et al. Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms. Brain. 1998;121:687–697
  10. Fisher E, Rudick RA, Cutter G, Baier M, Miller D, Weinstock-Guttman B, et al. Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients. Mult Scler. 2000;6:373–377
  11. Fox NC, Jenkins R, Leary SM, Stevenson VL, Losseff NA, Crum WR, et al. Progressive cerebral atrophy in MS: a serial study using registered, volumetric MRI. Neurology. 2000;54:807–812
  12. Gasperini C, Pozzilli C, Bastianello S, Giugni E, Horsfield MA, Koudriavtseva T, et al. Interferon-beta-1a in relapsing-remitting multiple sclerosis: effect on hypointense lesion volume on T1 weighted images. J Neurol Neurosurg Psychiatry. 1999;67:579–584
  13. Ge Y, Grossman RI, Udupa JK, Wei L, Mannon LJ, Polansky M, et al. Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: longitudinal quantitative analysis. Radiology. 2000;214:665–670
  14. Losseff NA, Wang L, Lai HM, Yoo DS, Gawne-Cain ML, McDonald WI, et al. Progressive cerebral atrophy in multiple sclerosis. A serial MRI study. Brain. 1996;119:2009–2019
  15. Simon JH, Jacobs LD, Campion MK, Rudick RA, Cookfair DL, Herndon RM, et al. A longitudinal study of brain atrophy in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Neurology. 1999;53:139–148
  16. Fisniku LK, Chard DT, Jackson JS, Anderson VM, Altmann DR, Miszkiel KA, et al. Gray matter atrophy is related to long-term disability in multiple sclerosis. Ann Neurol. 2008;64:247–254
  17. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol. 1987;149:351–356
  18. Miller DH, Leary SM. Primary-progressive multiple sclerosis. Lancet Neurol. 2007;6:903–912
  19. Wattjes MP, Harzheim M, Kuhl CK, Gieseke J, Schmidt S, Klotz L, et al. Does high-field MR imaging have an influence on the classification of patients with clinically isolated syndromes according to current diagnostic MR imaging criteria for multiple sclerosis?. AJNR Am J Neuroradiol. 2006;27:1794–1798
  20. Sicotte NL, Voskuhl RR, Bouvier S, Klutch R, Cohen MS, Mazziotta JC. Comparison of multiple sclerosis lesions at 1.5 and 3.0Tesla. Invest Radiol. 2003;38:423–427
  21. Bakshi R, Thompson AJ, Rocca MA, Pelletier D, Dousset V, Barkhof F, et al. MRI in multiple sclerosis: current status and future prospects. Lancet Neurol. 2008;7:615–625

PII: S0303-8467(09)00345-X

doi: 10.1016/j.clineuro.2009.12.012

Clinical Neurology and Neurosurgery
Volume 112, Issue 4 , Pages 286-290 , May 2010

Article Tools

* Image Usage & Resolution