Clinical Neurology and Neurosurgery
Volume 112, Issue 6 , Pages 474-477, July 2010

Gamma knife radiosurgery for intracranial cavernous malformations

  • Wang Peng
    • ,
  • Zhang Fangcheng
    • ,
  • Zhang Hongyun
    • ,
  • Zhao Hongyang

      Affiliations

    • Corresponding Author InformationCorresponding author at: Gamma Knife Center, Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Road, Hankou, Wuhan City 430022, Hubei Prov., China. Tel.: +86 2785780458.

Gamma Knife Center, Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Received 6 August 2009; received in revised form 6 January 2010; accepted 8 March 2010.

Abstract 

Objectives

To analyze and evaluate the role of Gamma knife radiosurgery (GKRS) and clinical outcome in patients with intracranial cavernous malformations.

Patients and methods

The medical records of 96 patients who underwent radiosurgery at our institute were reviewed retrospectively.

Results

After a mean follow-up period of 4.3 years, 33 cases out of 44 (75.0%) with complaint of seizure had cleared or got improved, 9 (20.5%) were not improved and 2 (4.5%) got worse. Of the 100 lesions in the 96 patients, 24 (24.0%) had the lesions shrinkage on the follow-up imagings. One patient (1.6%) with symptom of headache and dizziness got worse and three patients (3.1%) presented with new cranial nerve palsy. We have compared the treatment results between different marginal dose groups and find that low marginal dose can get better therapeutic efficacy but with less complications.

Conclusion

GKRS is an effective and microinvasive treatment option for intracranial cavernous malformations.

Keywords: Gamma knife, Radiosurgery, Cavernous malformation, Encephaledema, Complication, Seizure

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PII: S0303-8467(10)00070-3

doi:10.1016/j.clineuro.2010.03.012

Clinical Neurology and Neurosurgery
Volume 112, Issue 6 , Pages 474-477, July 2010

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