Clinical Neurology and Neurosurgery
Volume 112, Issue 6 , Pages 478-481, July 2010

Serum lipoprotein levels in patients with neuromyelitis optica elevated but had little correlation with clinical presentations

  • Ying Li

      Affiliations

    • These authors contributed equally to the manuscript.
    • ,
  • Honghao Wang

      Affiliations

    • These authors contributed equally to the manuscript.
    • ,
  • Xueqiang Hu

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +86 20 85252536; fax: +86 20 87567133.
    • ,
  • Fuhua Peng
    • ,
  • Yu Yang

Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, 600# Tianhe Road, Guangzhou, Guangdong 510630, China

Received 4 July 2009; received in revised form 3 March 2010; accepted 16 March 2010.

Abstract 

Objective

To explore the relationship between serum lipoproteins and clinical presentations of NMO patients. To investigate the differences of serum lipoprotein levels between NMO and MS patients.

Patients and methods

Serum lipoprotein levels were measured in 56 NMO patients, 53 MS patients and 54 health subjects. Serum lipoprotein levels in all participants and relevant clinical parameters of NMO patients were investigated. Statistical analyses were performed using the SPSS statistical software.

Results

NMO patients had significantly higher serum cholesterol (TC), triglyceride, low-density lipoprotein cholesterol, apolipoprotein B (apoB), lipoprotein (a) levels and TC/HDL-C, apoB/apoA-1 ratios than health control group. NMO patients had significantly higher serum apoB level and apoB/apoA-1 ratio than MS patients. There was little correlation between serum lipoproteins and NMO presentations.

Conclusion

The elevated lipoprotein levels in NMO patients could be just secondary changes with limited value in clinical prediction. However, elevated apoB level and apoB/apoA-1 ratio in NMO might indicate severer disability and might provide some useful information in the differential diagnosis with MS.

Keywords: Lipoproteins, Neuromyelitis optica, Multiple sclerosis, Inflammation

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PII: S0303-8467(10)00075-2

doi:10.1016/j.clineuro.2010.03.017

Clinical Neurology and Neurosurgery
Volume 112, Issue 6 , Pages 478-481, July 2010

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