Volume 112, Issue 7 , Pages 602-608, September 2010
Antiphospholipid syndrome and central nervous system
Abstract
Classification criteria, etiology, pathogenesis, major central nervous system (CNS) manifestations of the antiphospholipid syndrome (APS), as well as diagnostic and therapeutic approach are discussed in the article, supported by several MRI findings to illustrate differential complexity of selected topics. Close interplay of inflammation, autoimmunity, coagulation cascade, vasculature bed, neuron physiology and demyelinization in APS is elaborated. Cerebrovascular disease, multiple sclerosis-like syndrome, seizures, cognitive disfunction, headache and migraine, chorea and catastrophic antiphospholipid syndrome (CAPS) are discussed as the most prominent CNS manifestations of the APS.
Keywords: Antiphospholipid syndrome, Central nervous system, Autoimmunity, Thrombosis, Demyelinization
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PII: S0303-8467(10)00094-6
doi:10.1016/j.clineuro.2010.03.023
© 2010 Elsevier B.V. All rights reserved.
Volume 112, Issue 7 , Pages 602-608, September 2010
