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Volume 112, Issue 7, Pages 602-608 (September 2010)


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Antiphospholipid syndrome and central nervous system

Miroslav MayeraCorresponding Author Informationemail address, Mislav Ceroveca, Marko Radošb, Nada Čikeša

Received 10 March 2010; accepted 23 March 2010.

Abstract 

Classification criteria, etiology, pathogenesis, major central nervous system (CNS) manifestations of the antiphospholipid syndrome (APS), as well as diagnostic and therapeutic approach are discussed in the article, supported by several MRI findings to illustrate differential complexity of selected topics. Close interplay of inflammation, autoimmunity, coagulation cascade, vasculature bed, neuron physiology and demyelinization in APS is elaborated. Cerebrovascular disease, multiple sclerosis-like syndrome, seizures, cognitive disfunction, headache and migraine, chorea and catastrophic antiphospholipid syndrome (CAPS) are discussed as the most prominent CNS manifestations of the APS.

a University Hospital Center Zagreb, University of Zagreb, School of Medicine, Department of Medicine, Division of Clinical Immunology and Rheumatology, Kispaticeva ulica 12, 10000 Zagreb, Croatia

b University Hospital Center Zagreb, University of Zagreb, School of Medicine, Department of Diagnostic and Interventional Radiology, Kispaticeva ulica 12, 10000 Zagreb, Croatia

Corresponding Author InformationCorresponding author. Tel.: +385 12388330.

PII: S0303-8467(10)00094-6

doi:10.1016/j.clineuro.2010.03.023


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